Transdermal delivery of glyceryl trinitrate: clinical applications in acute stroke
نویسندگان
چکیده
منابع مشابه
Inhibition of platelet aggregation by transdermal glyceryl trinitrate.
OBJECTIVE To determine the optimum conditions for the demonstration of an antiplatelet effect of nitric oxide and to use these conditions to elucidate the effects of a transdermal glyceryl trinitrate patch on platelet aggregation in normal volunteers. METHODS An open prospective crossover study. The effects of nitric oxide on platelet aggregation in whole blood and platelet rich plasma as sti...
متن کاملFeasibility of an ambulance-based stroke trial, and safety of glyceryl trinitrate in ultra-acute stroke: the rapid intervention with glyceryl trinitrate in Hypertensive Stroke Trial (RIGHT, ISRCTN66434824).
BACKGROUND AND PURPOSE The practicalities of doing ambulance-based trials where paramedics perform all aspects of a clinical trial involving patients with ultra-acute stroke have not been assessed. METHODS We performed a randomized controlled trial with screening, consent, randomization, and treatment performed by paramedics prior to hospitalization. Patients with probable ultra-acute stroke ...
متن کاملTransdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke.
High blood pressure (BP) is common in acute stroke and is independently associated with a poor outcome. Lowering BP might improve outcome if it did not adversely affect cerebral blood flow (CBF) or cerebral perfusion pressure. We investigated the effect of glyceryl trinitrate ([GTN] an NO donor) on quantitative CBF, BP, and cerebral perfusion pressure in patients with recent stroke. Eighteen pa...
متن کاملUltra-Acute Stroke: The Rapid Intervention With Glyceryl Trinitrate in Hypertensive Feasibility of an Ambulance-Based Stroke Trial, and Safety of Glyceryl Trinitrate in
Sandeep Ankolekar, Michael Fuller, Ian Cross, Cheryl Renton, Patrick Cox, Nikola Sprigg, A. Stroke Trial (RIGHT, ISRCTN66434824) Ultra-Acute Stroke: The Rapid Intervention With Glyceryl Trinitrate in Hypertensive Feasibility of an Ambulance-Based Stroke Trial, and Safety of Glyceryl Trinitrate in Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2013 American Heart Association, Inc. All...
متن کاملTransdermal glyceryl trinitrate (nitroglycerin) in healthy persons: acute effects on skin temperature and hemodynamic orthostatic response.
In order to find an explanation for individual reactions to transdermal glyceryl trinitrate (GTN) we studied the skin temperature and hemodynamic reactions in 63 healthy persons. The data were obtained before and after the application of GTN and Glycerin (GL) placebo patches, during one hour. The skin temperature was measured on both forearms, the local (left sided) and systemic (right sided) r...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Delivery
سال: 2020
ISSN: 1742-5247,1744-7593
DOI: 10.1080/17425247.2020.1716727